MyBioSource.com's Neutrophil elastase Antibody (N-term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The Neutrophil elastase Antibody (N-term) was generated using ELA2, ELANE, elastase, HNE, Ne, and neutrophil elastase as the antigen and it reacts with Human.
Description
Elastases form a subfamily of serine proteases that
hydrolyze many proteins in addition to elastin. Humans have six
elastase genes which encode the structurally similar proteins. The
product of this gene hydrolyzes proteins within specialized
neutrophil lysosomes, called azurophil granules, as well as
proteins of the extracellular matrix following the protein's
release from activated neutrophils. The enzyme may play a role in
degenerative and inflammatory diseases by its proteolysis of
collagen-IV and elastin of the extracellular matrix. This protein
degrades the outer membrane protein A (OmpA) of E. coli as well as
the virulence factors of such bacteria as Shigella, Salmonella and
Yersinia. Mutations in this gene are associated with cyclic
neutropenia and severe congenital neutropenia (SCN). This gene is
clustered with other serine protease gene family members,
azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3
genes are expressed coordinately and their protein products are
packaged together into azurophil granules during neutrophil
differentiation